Subscribe to get Updates
Healthy Legacy
  • Home
  • Mind Memory Focus
  • Exercise & Fitness
  • Longevity & Anti Aging
  • Nutrition & Supplements
No Result
View All Result
  • Home
  • Mind Memory Focus
  • Exercise & Fitness
  • Longevity & Anti Aging
  • Nutrition & Supplements
No Result
View All Result
Healthy Legacy
No Result
View All Result

'Anti-aging molecule' could improve liver and kidney treatments

admin by admin
October 29, 2018
in Longevity & Anti Aging
0
'Anti-aging molecule' could improve liver and kidney treatments
Scientists have revealed that an enzyme that is present in the liver and kidneys limits the activity of a molecule that plays a role in cell metabolism and longevity. Their research suggests that blocking this enzyme could be a way to preserve the health of these organs.
Increasing levels of a so-called anti-aging molecule may boost treatments for diseases that affect the liver and kidneys.

Nicotinamide adenine dinucleotide (NAD+) is called the “anti-aging molecule” because research has shown that its levels fall with age and that restoring them can extend years of good health and even longevity itself.

This molecule plays a key role in several biological processes that help cells get energy and stay healthy, such as metabolism, DNA repair, gene expression, and cell signaling.

Scientists class NAD+ as a coenzyme, meaning that it does not act alone but helps the enzymes that drive these vital cell processes.

One family of enzymes that NAD+ has an ancient “intimate connection” with is the sirtuins.

Studies have shown that as NAD+ declines with age, it reduces sirtuin activity in ways that affect the communication between the cell nucleus and its mitochondria, which are the tiny compartments that produce energy for the cell.

Control of NAD+ is ‘evolutionarily conserved’

The recent study, which the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland led, features in the journal Nature. It demonstrates two compounds that could restore fallen levels of NAD+ in the liver and kidneys.

Cells synthesize NAD+ from scratch using the amino acid tryptophan as the main building block.

This “de novo synthesis” requires the presence of certain enzymes, including one called aminocarboxymuconate-semialdehyde decarboxylase (ACMSD), which has the effect of limiting the production of NAD+.

The team describe the way in which ACMSD controls NAD+ levels in cells as being “evolutionarily conserved.”

Their investigation demonstrated that the mechanism was the same in both Caenorhabditis elegans, a type of worm, and mice, and that blocking ACMSD increased both NAD+ and mitochondrial activity.

Selective ACMSD inhibitors

The researchers discovered that blocking ACMSD also raised the activity of one of the sirtuins that NAD+ works with. The combination of elevated sirtuin activity and increased NAD+ synthesis boosted mitochondrial activity.

Working with TES Pharma, the team then tested the effect of two selective ACMSD blockers in animal models of nonalcoholic fatty liver disease and kidney damage. Both compounds seemed to “preserve” liver and kidney function.

“Since the enzyme is mostly found in the kidneys and liver,” says first study author Elena Katsyuba, of the Interfaculty Institute of Bioengineering at EPFL, “we wanted to test the capacity of the ACMSD inhibitors to protect these organs from injury.”

As ACMSD does not occur elsewhere in the body, the finding could pave the way for a protective treatment that boosts NAD+ without affecting other organs.

“Put simply, the enzyme will not be missed by an organ that does not have it anyway.”

Elena Katsyuba

Tags: Urology / Nephrology
Advertisement Banner
Previous Post

Mental health conditions on the rise among US students

Next Post

Eye scan may detect Alzheimer's disease in seconds

admin

admin

Next Post
Eye scan may detect Alzheimer's disease in seconds

Eye scan may detect Alzheimer's disease in seconds

Sign Up for Our Newsletter

Join our subscribers list to get the latest news, updates and special offers delivered directly in your inbox.
This field is for validation purposes and should be left unchanged.

Recommended

New insights into how exercise can lift mood in depression

New insights into how exercise can lift mood in depression

3 years ago
Interaction between immunity and gut bacteria influences aging

Interaction between immunity and gut bacteria influences aging

4 years ago

Don't Miss

What Can a Depressed Person Eat in Winter?

What Can a Depressed Person Eat in Winter?

May 15, 2022
Are ‘Climate-Friendly’ Options on Restaurant Menus Coming Soon?

Are ‘Climate-Friendly’ Options on Restaurant Menus Coming Soon?

May 15, 2022
Is It Healthy to Eat Sauerkraut Daily?

Is It Healthy to Eat Sauerkraut Daily?

May 12, 2022
What Sweets Are Good for Diets?

What Sweets Are Good for Diets?

May 12, 2022
Healthy Legacy

Follow us

Recent News

What Can a Depressed Person Eat in Winter?

What Can a Depressed Person Eat in Winter?

May 15, 2022
Are ‘Climate-Friendly’ Options on Restaurant Menus Coming Soon?

Are ‘Climate-Friendly’ Options on Restaurant Menus Coming Soon?

May 15, 2022

Categories

  • Beauty
  • disease
  • Exercise & Fitness
  • immunity
  • Longevity & Anti Aging
  • Mind Memory Focus
  • Nature
  • Nutrition & Supplements
  • Seniors
  • Spices
  • Uncategorized

Tags

Acid Reflux / GERD ADHD / ADD Alcohol / Addiction / Illegal Drugs Alzheimer's / Dementia Anxiety / Stress Bipolar Cancer / Oncology Cardiovascular / Cardiology Cholesterol Complementary Medicine / Alternative Medicine COPD Dentistry Depression Dermatology Diabetes Diabetes Type 2 Eating Disorders Eye Health / Blindness GastroIntestinal / Gastroenterology Heart Disease Immune System / Vaccines Men's Health Mental Health Multiple Sclerosis Neurology / Neuroscience Nutrition / Diet Obesity / Weight Loss / Fitness Osteoarthritis Osteoporosis Parkinson's Disease Pharmacy / Pharmacist Psychology / Psychiatry Respiratory Rheumatoid Arthritis Schizophrenia Seniors / Aging Sexual Health / STDs Sleep / Sleep Disorders / Insomnia Sports Medicine / Fitness Stroke Urinary Tract Infection Urology / Nephrology Vegan / Vegetarian Veterinary Women's Health / Gynecology
  • About
  • Advertise
  • Privacy Policy
  • Contact

© 2018 Healthy Legacy

No Result
View All Result
  • Home
  • Mind Memory Focus
  • Exercise & Fitness
  • Longevity & Anti Aging
  • Nutrition & Supplements

© 2018 Healthy Legacy